I: myo-Inositol Metabolism and Homeostasis. - The Mechanism of Enzymatic Isomerization of Glucose 6-Phosphate to L-myo-Inositol 1-Phosphate. - Regulation of the Lipid Composition of Lung Surfactant. - Nutritional Regulation of the Composition Metabolism and Function of Cellular Phosphatidylinositol. - Detection of Receptor-Linked Phosphoinositide Metabolism in Brain of Lithium-Treated Rats. - Propranolol-Induced Membrane Perturbation and the Metabolism of Phosphoinositides and Arachidonoyl Diacylglycerols in the Retina. - Neurotransmitter Receptor-Mediated myo-Inositol 1-Phosphate Accumulation in Hippocampal Slices. - Early Events in the Selective Cytotoxicity to Tumor Cells Induced by Liposomes Containing Plant Phosphatidylinositol. - Discussion. - II: Phosphoinositide Biosynthesis and Degradation. - Phosphatidylinositol Synthase in Mammalian Pancreas. - The Enzymology of Phosphoinositide Catabolism with Particular Reference to Phosphatidylinositol 45-Bisphosphate Phosphodiesterase. - Subcellular Sites of Polyphosphoinositide Metabolism in Rat Liver. - Loss of Phosphatidylinositol and Gain in Phosphatidate in Neutrophils Stimulated with FMet-Leu-Phe. - The De Novo Phospholipid Synthesis Effect: Occurrence Characteristics Underlying Mechanisms and Functional Significance in Hormone Action and Secretion. - Hydrolysis of Phosphatidylinositol 4-Phosphate and Phosphatidylinositol(45)-Bisphosphate by Specific Phosphomonoesterases in Human Erythrocytes. - Drug-Induced Modifications of Phosphoinositide Metabolism. - Discussion. - III: Receptor-Mediated Alterations in Phosphoinositide Metabolism. - Inositol Lipid Breakdown in Receptor-Mediated Responses of Sympathetic Ganglia and Sympathetically Innervated Tissues. - Hormone Effects on Phosphoinositide Metabolism in Liver. - Relationship Between Vasopressin Activation of Rat Hepatocyte Glycogen Phosphorylase Inhibition of Ca2+-Mg2+-ATPase and Phosphoinositide Breakdown. - Polyphosphoinositides and Muscarinic Cholinergic and ?1-Adrenergic Receptors in the Iris Smooth Muscle. - The Phosphatidylinositol Effect in the Retina: Role of Light and Neurotransmitters. - Ca2+-Mobilizing Agonists Stimulate a Polyphosphoinositide-Specific Phospholipase C in Rat Parotid Gland. - Phosphatidylinositol Degradation is Directly Proportional to the Rate of Cell Division in Embryonic Chicken Lens Epithelia. - Discussion. - IV: Phosphoinositides Calcium and Protein Phosphorylation. - Messages of the Phosphoinositide Effect. - Inositol Trisphosphate and Calcium Mobilization. - Calcium-Phosphatidylinositol Interactions in Secretory Cells and the Role of Arachidonic Acid. - Calcium and Inositol Phospholipid Degradation in Signal Transduction. - The Role of Phosphoprotein B-50 in Phosphoinositide Metabolism in Brain Synaptic Plasma Membranes. - Purification of Protein Kinase C and Phorbol Ester Receptor Using Polyacrylamide-Immobilized Phosphatidylserine. - Second Messenger Role of Inositol Trisphosphate for Mobilization of Intracellular Calcium in Liver. - Discussion. - V: Phosphoinositides and Arachidonic Acid Mobilization. - Mechanisms for Eicosanoid Precursor Uptake and Release by a Tissue Culture Cell Line. - The Mobilization of Arachidonate and Metabolism of Phosphoinositides in Stimulated Human Platelets. - The Relevance of Inositide Degradation and Protein Kinase C in Platelet Responses. - Regulation of Arachidonic Acid Release for Prostaglandin Production During Parturition. - Is Phosphatidylinositol Involved in the Release of Free Fatty Acids in Cerebral Ischemia?. - Endogenous Phospholipid Metabolism in Stimulated Human Platelets: ALink Between Inositide Breakdown and Calcium Mobilization. - Phosphatidylinositol Turnover in Madin-Darby Canine Kidney Cells: Comparison of Stimulation by A23187 and 12-O-Tetradecanoyl-Phorbol-13-Acetate. - Discussion. - VI: Phosphoinositide Metabolism in the Nervous System. - Inositol Sorbitol and Diabetic Neuropathy. - Altered Nerve myo-lnositol Metabolism in Experimental Diabetes and Its Relationship to Nerve Function. - Changes in Peripheral Nerve Polyphosphoinositide Metabolism in Experimental Diabetes: Nature and Significance. - Relationship of Inositol Phosphatidylinositol and Phosphatidic Acid in CNS Nerve Endings. - Polyphosphoinositide Turnover in the Nervous System. - Metabolism of Inositol-Containing Phospholipids in the Superior Cervical Ganglion of the Rat. - Discussion. - Concluding RemarksA Bright Future. - Abstracts. - Index of Abstract Authors. Language: English